iBio Acquires RubrYc Therapeutics’ AI Drug Discovery

– Positions Firm for management in AI-powered drug discovery –

– Expands iBio’s immuno-oncology pipeline with three new candidates –

– Internet hosting investor name on September twenty seventh to debate transaction, the Firm’s transformation and FY2022 monetary outcomes –

SAN DIEGO and BRYAN, Texas, Sept. 21, 2022 (GLOBE NEWSWIRE) — iBio, Inc. (NYSEA:IBIO) (“iBio” or the “Firm”), a developer of next-generation biopharmaceuticals and pioneer of the sustainable FastPharming® Manufacturing System, at present introduced that it closed on the acquisition of considerably all the property of its accomplice, RubrYc Therapeutics, Inc. (“RubrYc”) after it entered right into a definitive asset buy settlement (the “Buy Settlement”). The transaction marks one other necessary step towards iBio’s mission to deliver extra – and higher – immunotherapies to the clinic, quicker, with its continued transformation right into a biopharmaceutical discovery and growth firm.

The acquired property embrace:

  • AI Drug Discovery Platform: A patented system that makes use of synthetic intelligence (“AI”) to design 3D fashions of epitopes to facilitate the creation of higher antibody drug candidates. In contrast to different conventional and newer AI-driven strategies of drug discovery that always focus upon dominant epitopes, the RubrYc Discovery Engine makes use of predictive algorithms to determine and mannequin subdominant and conformational epitopes, prospectively enabling the invention of recent antibody therapies for hard-to-target cancers and different ailments.
  • Beforehand Licensed Candidates: All rights – with no future milestone funds or royalty obligations – to 2 molecules. These embrace IBIO-101, an IL-2 sparing anti-CD25 antibody for depletion of regulatory T cells, in addition to “Goal 6” that was found in Q2 FY2022 utilizing the Discovery Engine.
  • New Therapeutic Candidates: Three promising immuno-oncology candidates, plus a partnership-ready PD-1 agonist for severe autoimmune ailments, reminiscent of systemic lupus erythematosus and a number of sclerosis.

Buy phrases embrace:

  • An upfront cost of $1 million in iBio’s widespread inventory to RubrYc buyers.
  • Eligibility for RubrYc’s buyers to obtain as much as $5 million in growth milestones over the subsequent 5 years, to be paid in widespread inventory or money, at iBio’s sole discretion.

In an effort to focus its assets on the promising new discovery platform and getting into the clinic with its lead compounds, iBio has initiated a overview of alternatives to speed up its transformation whereas extending its money runway past earlier steering of September 30, 2023. These embrace asset gross sales, partnerships, portfolio selections, value reductions, and non-dilutive efforts to lift further capital.

“We’re excited to pair our new AI Discovery Engine with our current platforms to create a biotech firm with its personal end-to-end discovery capabilities and an expanded pipeline of immunotherapy candidates,” mentioned Tom Isett, Chairman & Chief Govt Officer of iBio. “We’re additionally completely satisfied to welcome 4 of RubrYc’s proficient and skilled computational biology pioneers to our workforce, the vast majority of whom will make the transfer to iBio’s new Drug Discovery Heart that’s slated to open in San Diego within the coming weeks.”

“As an alternative of counting on conventional ‘trial-and-error’ drug screening strategies, we consider including an AI-powered discovery functionality to the entrance finish of our course of will allow us to deliver higher molecules into the clinic quicker and extra cost-effectively,” commented Martin Brenner, DVM. Ph.D., iBio’s Chief Scientific Officer. “This was clearly demonstrated with iBio’s pipeline Goal 6, a mutated type of a protein expressed in numerous tumors. RubrYc’s Discovery Engine enabled the speedy identification of antibodies that selectively bind the mutated protein, with out binding the wild-type model, which is extra generally expressed in wholesome tissues. As a result of distinctive traits of the RubrYc Discovery Engine, we have been capable of expeditiously advance this system from the Early Discovery to the Late Discovery stage.”

The closing of the acquisition was conditioned upon approval of the NYSE American and each events assembly different customary closing situations.

Webcast and Convention Name

​The Firm will report its fiscal fourth quarter and full yr 2022 monetary outcomes after market shut on Tuesday, September 27, 2022, and can host a webcast and convention name at 4:30 p.m. Jap Time to debate the outcomes, give extra data on the RubrYc transaction and strategic overview, and supply further updates. The dwell and archived webcast could also be accessed on the Firm’s web site at www.ibioinc.com beneath “Information and Occasions” within the Traders part. To entry the dwell name by cellphone, members ought to go to this registration hyperlink, the place they are going to be supplied with the dial-in particulars.

About iBio, Inc.

iBio develops next-generation biopharmaceuticals utilizing computational biology and 3D-modeling of hard-to-target subdominant epitopes together with its sustainable, plant-based protein expression capabilities for cGMP manufacturing. Its FastPharming® Manufacturing System combines vertical farming, automated hydroponics, and novel glycosylation applied sciences to quickly ship high-quality monoclonal antibodies, vaccines, bioinks and different proteins. iBio is growing proprietary biopharmaceuticals for the therapy of cancers, in addition to fibrotic, infectious and autoimmune ailments. The Firm’s wholly owned subsidiary, iBio CDMO LLC, supplies FastPharming Contract Improvement and Manufacturing Providers together with Glycaneering Improvement Providers for superior recombinant protein engineering. For extra data, go to www.ibioinc.com.

Ahead-Wanting Statements

Sure statements on this press launch represent “forward-looking statements” inside the that means of the federal securities legal guidelines. Phrases reminiscent of “might,” “may,” “will,” “ought to,” “consider,” “count on,” “anticipate,” “estimate,” “proceed,” “predict,” “forecast,” “venture,” “plan,” “intend” or related expressions, or statements concerning intent, perception, or present expectations, are forward-looking statements. These forward-looking statements are primarily based upon present estimates and assumptions and embrace statements concerning iBio’s mission to deliver extra – and higher –immunotherapies to the clinic, quicker; including an AI-powered discovery functionality to the entrance finish of the method; and enabling the Firm to deliver higher molecules into the clinic quicker and extra cost-effectively. Whereas the Firm believes these forward-looking statements are affordable, undue reliance shouldn’t be positioned on any such forward-looking statements, that are primarily based on data obtainable to the Firm on the date of this launch. These forward-looking statements are topic to varied dangers and uncertainties, lots of that are tough to foretell that might trigger precise outcomes to vary materially from present expectations and assumptions from these set forth or implied by any forward-looking statements. Necessary elements that might trigger precise outcomes to vary materially from present expectations embrace, amongst others, the Firm’s means to deliver higher molecules into the clinic quicker and extra cost-effectively; the flexibility to acquire regulatory approval for commercialization of its product candidates, or to adjust to ongoing regulatory necessities; regulatory limitations regarding its means to advertise or commercialize its product candidates for particular indications; acceptance of its product candidates within the market and the profitable growth, advertising and marketing or sale of merchandise; the flexibility to fund its applications and lift capital when wanted; and the opposite elements mentioned within the Firm’s filings with the SEC together with the Firm’s Annual Report on Type 10-Okay for the yr ended June 30, 2021 and the Firm’s subsequent filings with the SEC on Kinds 10-Q and 8-Okay. The data on this launch is supplied solely as of the date of this launch, and the Firm undertakes no obligation to replace any forward-looking statements contained on this launch on account of recent data, future occasions, or in any other case, besides as required by regulation.


Stephen Kilmer
iBio, Inc.
Investor Relations
(646) 274-3580

Susan Thomas 
iBio, Inc. 
Media Relations 
(619) 540-9195 


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